abstract：OBJECTIVES:Different studies suggest that inflammation as well as hypoxia leads to an increase of p53 protein levels. However, the implication of p53 during oral inflammatory processes is still unknown. The aim of this study was therefore to investigate the effect of hypoxia and inflammation on p53 regulation in human ...

journal_title：Clinical oral investigations

authors： Memmert S,Gölz L,Pütz P,Jäger A,Deschner J,Appel T,Baumgarten G,Rath-Deschner B,Frede S,Götz W

更新日期：2016-09-01 00:00:00

abstract：OBJECTIVE:Aggregatibacter actinomycetemcomitans, specially its highly leucotoxic strain (JP2 clone), represents an etiological factor for the onset and progression of aggressive types of periodontitis. The aims of this investigation were to investigate the most relevant periodontal pathogens in the subgingival microbio...

journal_title：Clinical oral investigations

authors： Mínguez M,Ennibi OK,Pousa X,Lakhdar L,Abdellaoui L,Sánchez M,Sanz M,Herrera D

更新日期：2016-09-01 00:00:00

abstract：OBJECTIVES:The purpose of this study is to compare pressures at the apical foramen created by conventional syringe irrigation and the GentleWave™ System, which releases high-velocity degassed irrigants to the pulp chamber and uses broad-spectrum sound energy for cleaning. MATERIALS AND METHODS:The apical pressure gene...

journal_title：Clinical oral investigations

authors： Haapasalo M,Shen Y,Wang Z,Park E,Curtis A,Patel P,Vandrangi P

更新日期：2016-09-01 00:00:00

abstract：OBJECTIVES:In this in vitro study, we assessed filling characteristics (adaptation, homogeneity, sealer percentage, position of the carrier) of warm and cold obturation methods in curved root canals. MATERIALS AND METHODS:A reciprocating method was used to prepare 90 curved roots (25 ° average curvature) to an apical ...

journal_title：Clinical oral investigations

authors： Neuhaus KW,Schick A,Lussi A

更新日期：2016-09-01 00:00:00

abstract：OBJECTIVES:The purpose of this prospective clinical trial was to examine the clinical and patient outcomes following esthetic reconstruction of interdental papilla loss in anterior teeth, using an injectable, non-animal-based, hyaluronic acid gel. MATERIALS AND METHODS:Ten systemically healthy adults, with at least on...

journal_title：Clinical oral investigations

authors： Awartani FA,Tatakis DN

更新日期：2016-09-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to evaluate the 12-year clinical performance of sintered (Duceram, Dentsply-Degussa, Dentsply International Inc., PA, USA)-D and pressable (IPS Empress, Ivoclar-Vivadent, Schaan, Leichtenstein)-IPS ceramic inlay and onlay restorations. METHODS:Eighty-six restorations were placed in...

journal_title：Clinical oral investigations

authors： Santos MJ,Freitas MC,Azevedo LM,Santos GC Jr,Navarro MF,Francischone CE,Mondelli RF

更新日期：2016-09-01 00:00:00

abstract：OBJECTIVE:This study compared the effects of mold material and diameter on the thickness of cured composite remnants and depth of cure (DOC) of resin-based composites (RBC). MATERIAL AND METHODS:One Polywave® curing light was used to photo-cure two shades of the same "bulk-fill" RBC in 4, 6, or 10-mm internal diameter...

journal_title：Clinical oral investigations

authors： Price RB,Rueggeberg FA,Harlow J,Sullivan B

更新日期：2016-09-01 00:00:00

abstract：OBJECTIVES:This study evaluated the influence of different rehydration media and time periods on biomechanical and structural properties of different acellular collagen matrices (ACMs). MATERIALS AND METHODS:Specimens of three ACMs (mucoderm®, Mucograft®, Dynamatrix®) were rehydrated in saline solution (SS) or human b...

journal_title：Clinical oral investigations

authors： Kasaj A,Levin L,Stratul SI,Götz H,Schlee M,Rütters CB,Konerding MA,Ackermann M,Willershausen B,Pabst AM

更新日期：2016-07-01 00:00:00

abstract：OBJECTIVES:Transglutaminase-2 (TGM-2) protein is involved in the cross-linking of matrix proteins resulting in several fibrotic disorders and can be induced by reactive oxygen species (ROS). Little is known about its role in the development of oral submucocal fibrosis (OSF). Hence, we hypothesize that TGM-2 may have a ...

journal_title：Clinical oral investigations

authors： Lee SS,Chen YJ,Tsai CH,Huang FM,Chang YC

更新日期：2016-06-01 00:00:00

abstract：OBJECTIVES:This prospective randomized clinical trial aimed to evaluate the long-term behavior of metal-free double crown retained dentures with secondary crowns and dental frameworks made of the fiber-reinforced composite Vectris(©) on all-ceramic primary crowns (IPS Empress 2(©)) over a period of up to 14 years and t...

journal_title：Clinical oral investigations

authors： Zahn T,Zahn B,Janko S,Weigl P,Gerhardt-Szép S,Lauer HC

更新日期：2016-06-01 00:00:00

abstract：OBJECTIVES:This case series compared the clinical survival of tooth-implant-supported (TI-S) and tooth-supported (T-S) three-unit fixed dental prostheses (FDPs) with zirconia frameworks and described the incidence of biological and technical complications. MATERIALS AND METHODS:Forty-four patients received 27 TI-S FDP...

journal_title：Clinical oral investigations

authors： Beuer F,Sachs C,Groesser J,Gueth JF,Stimmelmayr M

更新日期：2016-06-01 00:00:00

abstract：OBJECTIVES:The aims of this study were to determine the quality of life of periodontally compromised patients after implant treatment (primary aim) and their satisfaction with the restoration and treatment approach (secondary aim). MATERIAL AND METHODS:In this study, 61 adult subjects were evaluated following non-surg...

journal_title：Clinical oral investigations

authors： Fischer KR,Lindner I,Fickl S

更新日期：2016-05-01 00:00:00

abstract：OBJECTIVES:The objective of this study was to evaluate the inhibition of demineralization around enamel-dentin/restoration interface after dentin pretreatment with 2.5% titanium tetrafluoride (TiF4). MATERIALS AND METHODS:Forty dental class V cavities at the cementoenamel junction were distributed into four groups (n ...

journal_title：Clinical oral investigations

authors： Bridi EC,do Amaral FL,França FM,Turssi CP,Basting RT

更新日期：2016-05-01 00:00:00

abstract：OBJECTIVE:The objective of this study is to examine the efficacy of erlotinib and gefitinib with respect to epidermal growth factor (EGF) and cetuximab response in head and neck cancer cell lines. MATERIALS AND METHODS:Five human head and neck carcinoma cell lines were treated with EGF, cetuximab, erlotinib, and gefit...

journal_title：Clinical oral investigations

authors： Hartmann S,Neckel N,Seher A,Mutzbauer G,Brands RC,Linz C,Kübler AC,Müller-Richter UD

更新日期：2016-05-01 00:00:00

abstract：OBJECTIVES:This study aimed to conduct a methodological assessment of paper-based systematic reviews (SR) published in oral health using a validated checklist. A secondary objective was to explore temporal trends on methodological quality. MATERIAL AND METHODS:Two electronic databases (OVID Medline and OVID EMBASE) we...

journal_title：Clinical oral investigations

authors： Wasiak J,Shen AY,Tan HB,Mahar R,Kan G,Khoo WR,Faggion CM Jr

更新日期：2016-04-01 00:00:00

abstract：OBJECTIVES:To evaluate the marginal and internal fit of CAD/CAM-generated frameworks for 4-unit, fixed dental prostheses (FDPs) from zirconia (Z) and cobalt-chromium alloy (C) made with conventional (CI) and digital impressions (DI). MATERIALS AND METHODS:A titanium model was digitized with an intraoral scanner (DI, L...

journal_title：Clinical oral investigations

authors： Ueda K,Beuer F,Stimmelmayr M,Erdelt K,Keul C,Güth JF

更新日期：2016-03-01 00:00:00

abstract：OBJECTIVES:This study aims to compare the clinical outcomes of a combination of enamel matrix derivatives (EMD) and a synthetic bone graft (biphasic calcium phosphate) with EMD alone in wide and deep one- and two-wall intrabony defects 36 months after treatment. MATERIAL AND METHODS:Thirty patients with chronic period...

journal_title：Clinical oral investigations

authors： Hoffmann T,Al-Machot E,Meyle J,Jervøe-Storm PM,Jepsen S

更新日期：2016-03-01 00:00:00

abstract：OBJECTIVES:Facial asymmetries in oculoauriculovertebral spectrum (OAVS) patients might require surgical corrections that are mostly based on qualitative approach and surgeon's experience. The present study aimed to develop a quantitative 3D CT imaging-based procedure suitable for maxillo-facial surgery planning in OAVS...

journal_title：Clinical oral investigations

authors： Manara R,Schifano G,Brotto D,Mardari R,Ghiselli S,Gerunda A,Ghirotto C,Fusetti S,Piacentile K,Scienza R,Ermani M,Martini A

更新日期：2016-03-01 00:00:00

abstract：OBJECTIVE:This study investigated the effect of passive ultrasonic irrigation (PUI) on diffusion of hydroxyl ions through radicular dentine. MATERIALS AND METHODS:After chemomechanical preparation of root canals in 60 human teeth, the cementoenamel junction and the apical 3 mm of each root were covered with fast-setti...

journal_title：Clinical oral investigations

authors： Cidade FH,Schmidt TF,Dos Santos LG,Tay FR,da Silveira Teixeira C,Felippe MC,Bortoluzzi EA

更新日期：2016-03-01 00:00:00

abstract：OBJECTIVE:The purpose of this study was to assess current opinions, applied techniques, and materials for the restoration of endodontically treated teeth (ETT) in a nationwide survey in Germany. MATERIAL AND METHODS:Completed questionnaires from 1,648 dentists were returned (response rate 63%). RESULTS:In general, po...

journal_title：Clinical oral investigations

authors： Naumann M,Neuhaus KW,Kölpin M,Seemann R

更新日期：2016-03-01 00:00:00

abstract：OBJECTIVES:This study examines accuracy of dental impressions and following plaster models taken during treatment with fixed appliances. MATERIALS AND METHODS:A maxillary typodont was provided with brackets. Three examiners took impressions three times each of the variants: brackets only, archwire fixed by alastics, l...

journal_title：Clinical oral investigations

authors： Wriedt S,Foersch M,Muhle JD,Schmidtmann I,Wehrbein H

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Long-term culture system is used to prevent the impediment of insufficient cells and is good for low starting materials such as dental pulp or periodontal ligament. In general, although cell viability and functionality are the most common aspects taken into consideration in culturing cells for...

journal_title：Clinical oral investigations

authors： Jayaraman P,Govindasamy V,Gnanasegaran N,Kunasekaran W,Vasanthan P,Musa S,Kasim NH

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVES:Bony reconstruction of jaw defects using the free fibular flap and dental rehabilitation mostly requires insertion of dental implants within the transferred fibula bone. The aim of this paper was to discuss results of the implant stability with data on the possible benefit for the patient's quality of life a...

journal_title：Clinical oral investigations

authors： Jacobsen HC,Wahnschaff F,Trenkle T,Sieg P,Hakim SG

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Cleft lip and palate (CLP) represents the most common malformation of the midfacial region worldwide. It can be suggested that the facial stigmatization, the speech impediment, and the long-standing pressure of treatment cause a range of life stressors. Neurocortical information is influenced by physiologica...

journal_title：Clinical oral investigations

authors： Gassling V,Receveur K,Niederberger U,Koos B,Overath CH,Birkenfeld F,Wiltfang J,Gerber WD,Siniatchkin M

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVES:The main objective of this study was to evaluate clinical and radiographic outcomes of implant-supported fixed partial prostheses, comparing platform switching and standard platform concepts. MATERIALS AND METHODS:Patients with single or multiple partial edentulism were included in this prospective multicen...

journal_title：Clinical oral investigations

authors： Del Fabbro M,Bianchessi C,Del Lupo R,Landi L,Taschieri S,Corbella S

更新日期：2015-12-01 00:00:00

abstract：OBJECTIVES:The aim of this research was to analyse the dental discolouration caused by mineral trioxide aggregate (MTA) induced by bismuth oxide and also assess the colour stability of other dental cements. MATERIALS AND METHODS:Bismuth oxide, calcium tungstate and zirconium oxide were placed in contact with sodium hy...

journal_title：Clinical oral investigations

authors： Marciano MA,Duarte MA,Camilleri J

更新日期：2015-12-01 00:00:00

abstract：OBJECTIVES:The purpose of this study was to assess the efficacy of different cleansing agents in killing mixed species biofilms on silicone facial prostheses. MATERIALS AND METHODS:Two bacterial and three yeast strains, isolated from silicone facial prostheses, were selected for the mixed species biofilms. A variety o...

journal_title：Clinical oral investigations

authors： Ariani N,Visser A,Teulings MR,Dijk M,Rahardjo TB,Vissink A,van der Mei HC

更新日期：2015-12-01 00:00:00

abstract：OBJECTIVES:This study aimed to evaluate whether a specific interleukin-1 receptor-associated kinase-4 (IRAK4) gene polymorphism had any influence on the development of changes in maxillary sinus, particularly in the presence of etiological factors of dental origin. MATERIALS AND METHODS:The study population included 1...

journal_title：Clinical oral investigations

authors： Pereira IG,Vaz P,Almeida RF,Braga AC,Felino A

更新日期：2015-11-01 00:00:00

abstract：OBJECTIVES:The present case-control study aims to assess the occurrence of alexithymic traits in burning mouth syndrome (BMS) subjects and to correlate alexithymic traits to anxious and depressive traits in BMS subjects. MATERIALS AND METHODS:Prospectively enrolled BMS and control subjects were administered the 20-ite...

journal_title：Clinical oral investigations

authors： Marino R,Picci RL,Ferro G,Carezana C,Gandolfo S,Pentenero M

更新日期：2015-11-01 00:00:00

abstract：OBJECTIVES:Geranylgeraniol (GGOH) has been reported as a potential treatment option for bisphosphonate-associated osteonecrosis of the jaws (BP-ONJ). The aim of this study was to analyze the effects of GGOH on endothelial progenitor cells (EPC) after bisphosphonate treatment in vitro. MATERIALS AND METHODS:EPC were in...

journal_title：Clinical oral investigations

authors： Pabst AM,Krüger M,Ziebart T,Jacobs C,Walter C

更新日期：2015-09-01 00:00:00

abstract：OBJECTIVES:Bisphosphonates and denosumab are antiresorptive drugs used for the treatment of osteoporosis and oncological tumors. A severe side effect is osteonecrosis of the jaw. Monocyte/macrophage dysfunction is considered to play a distinct role in osteonecrosis. THP-1 monocytic cells were used in this study to eluc...

journal_title：Clinical oral investigations

authors： Hoefert S,Hoefert CS,Albert M,Munz A,Grimm M,Northoff H,Reinert S,Alexander D

更新日期：2015-07-01 00:00:00

abstract：OBJECTIVES:Nitrogen-containing bisphosphonates induce osteonecrosis mostly in the jaw and less frequently in other bones. Because of the crucial role of periosteal perfusion in bone repair, we investigated zoledronate-induced microcirculatory reactions in the mandibular periosteum in comparison with those in the tibia ...

journal_title：Clinical oral investigations

authors： Janovszky Á,Szabó A,Varga R,Garab D,Boros M,Mester C,Beretka N,Zombori T,Wiesmann HP,Bernhardt R,Ocsovszki I,Balázs P,Piffkó J

更新日期：2015-07-01 00:00:00

abstract：OBJECTIVES:The aim of this investigation was to assess the currently available evidence concerning the complications and risk factors influencing the outcome of autotransplantation of teeth in humans. MATERIALS AND METHODS:Electronic searches were conducted to identify randomized controlled and prospective clinical tr...

journal_title：Clinical oral investigations

authors： Almpani K,Papageorgiou SN,Papadopoulos MA

更新日期：2015-07-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to investigate the chemokine expression profiles in gingival crevicular fluid (GCF) and serum in patients with advanced chronic periodontitis and to assess the impact of smoking on local and systemic levels of chemokines. MATERIALS AND METHODS:Thirty patients with chronic periodonti...

journal_title：Clinical oral investigations

authors： Haytural O,Yaman D,Ural EC,Kantarci A,Demirel K

更新日期：2015-06-01 00:00:00

abstract：OBJECTIVES:Bisphosphonate-associated osteonecrosis of the jaw is a severe side effect in patients receiving nitrogen-containing bisphosphonates (N-BPs). One characteristic is its high recurrence rate; therefore, basic research for new therapeutic options is necessary. N-BPs inhibit the farnesylpyrophosphate synthase in...

journal_title：Clinical oral investigations

authors： Hagelauer N,Ziebart T,Pabst AM,Walter C

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND:The use of the autogenous periosteal graft as biological barrier has been proposed for periodontal regeneration. The aim of this study was to evaluate the histometric findings of the subepithelial connective tissue graft as barrier in intrabony defects compared to a bioabsorbable membrane. METHODS:Three-wal...

journal_title：Clinical oral investigations

authors： Ribeiro FS,Pontes AE,Zuza EP,da Silva VC,Lia RC,Marcantonio Junior E

更新日期：2015-06-01 00:00:00

abstract：OBJECTIVES:Numerous different attachments are used to retain overdentures on implants. The purpose of this study was to evaluate a new chairside attachment system based on polyvinylsiloxane (PVS). MATERIAL AND METHODS:A total of 250 specimens were fabricated (n = 10) to measure the retention force (RF) in dependence o...

journal_title：Clinical oral investigations

authors： Schweyen R,Beuer F,Arnold C,Hey J

更新日期：2015-05-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to establish the prevalence of celiac disease (CD) in patients with erosive and reticular form of oral lichen planus (OLP) compared to healthy controls. MATERIALS AND METHODS:Tissue transglutaminase antibodies (anti-tTG) and antibodies against gliadin (AGA) were measured in the ser...

journal_title：Clinical oral investigations

authors： Cigic L,Gavic L,Simunic M,Ardalic Z,Biocina-Lukenda D

更新日期：2015-04-01 00:00:00

abstract：OBJECTIVES:BioAggregate™ is a novel material introduced for use as a root-end filling material. It is tricalcium silicate-based, free of aluminium and uses tantalum oxide as radiopacifier. BioAggregate contains additives to enhance the material performance. The purpose of this research was to characterize the un-hydrat...

journal_title：Clinical oral investigations

authors： Camilleri J,Sorrentino F,Damidot D

更新日期：2015-04-01 00:00:00

abstract：OBJECTIVES:This study aims to test the influence of different surface treatments and conditioning on the shear bond strength between polyetherketone (PEEK) and composite. MATERIALS AND METHODS:Surfaces (570 plates) were used untreated, etched, air-particle abraded or activated with silica-modified alumina oxide. Surfa...

journal_title：Clinical oral investigations

authors： Rosentritt M,Preis V,Behr M,Sereno N,Kolbeck C

更新日期：2015-04-01 00:00:00